How to understand Panorama results?
What are test's limitations?
When will I receive Panorama results?
• A ‘low risk’ result indicates a reduced chance that your fetus has the above listed chromosome abnormalities, but does not guarantee normal chromosomes or a healthy baby.
• A “high risk” result indicates that there is an increased likelihood your fetus has one of the chromosome abnormalities tested but does not confirm that the fetus has that abnormality. Prenatal diagnostic testing, such as chorionic villus sampling (CVS) or amniocentesis, or testing the baby after delivery, is recommended for confirmation, before any irreversible decision is made. Your healthcare provider will discuss recommended follow-up steps with you, which may include referral to a specialist.
• There is a chance that the sample(s) submitted will not return results or will return partial results; depending upon a variety of factors, a redraw may or may not be accepted. A repeat sample does not always return a result. Women who do not receive a result from Panorama may be at unchanged or increased risk to be carrying a baby with a chromosome abnormality. If your Panorama test does not return a result, you should discuss options for further evaluation with your doctor, including the availability of genetic counseling, comprehensive ultrasound evaluation, and the option of diagnostic testing.
Although Panorama will detect the majority of pregnancies in which the fetus has one of the above listed chromosomal abnormalities, it cannot detect 100% of pregnancies with these conditions.
The results of this test do not eliminate the possibility of other abnormalities of the tested chromosomes, and it does not detect abnormalities of untested chromosomes, other genetic disorders, birth defects, or other complications in your fetus.
Inaccurate test results or a failure to obtain test results for one or more conditions may occur due to one or more of the following rare occurrences:
• courier/shipping delay,
• sample contamination or degradation,
• too little DNA from the fetus in the maternal blood sample,
• mosaicism (a mixture of cells with normal and abnormal chromosomes) in the fetus, placenta or mother,
• other genetic variants in the mother or fetus
• or other circumstances beyond our control
About 1 to 2% of all pregnancies have confined placental mosaicism – a situation in which the placenta has cells with a chromosome abnormality, while the fetus has normal chromosomes, or vice versa. This means that there is a chance that the chromosomes in the fetus may not match the chromosomes in the DNA screened from the placenta.
This test cannot be performed on patients who are carrying more than two babies (triplets or more), on patients who are carrying multiple babies (twin, triplets, etc.) where there is also an egg donor or surrogate, on pregnancies with a vanishing twin, or pregnancies in which the mother had a prior bone marrow/solid organ transplant.
You will receive your results through your healthcare provider usually in seven to ten calendar days.
Panorama gives you a personalized probability score and tells you if there is a high or low probability that your pregnancy may be affected by screened conditions such as Down syndrome. Like other screening tests, Panorama does not provide a definitive diagnosis of the condition.
What do Panorama results tell me?
A small, missing piece of a chromosome is called a microdeletion. Unlike Down syndrome, which occurs more frequently in mothers who are 35 and older, microdeletions occur in pregnancies at the same rate for mothers of any age.
Panorama screens for five microdeletion syndromes associated with serious health problems:
• 22q11.2 deletion (DiGeorge) syndrome
• 1p36 deletion syndrome
• Angelman syndrome
• Prader-Willi syndrome
• Cri-du-chat syndrom.
What are microdeletions?
• Trisomy 21 (Down syndrome)
• Trisomy 18 (Edwards syndrome)
• Trisomy 13 (Patau syndrome)
• Gender (optional
Egg donor or surrogate pregnancies:
Twin pregnancies:
• Identical or fraternal twins
• Trisomy 21 (Down syndrome)
• Trisomy 18 (Edwards syndrome)
• Trisomy 13 (Patau syndrome)
• Gender of each twin (optional)
If our screening finds that your twins are identical, Panorama can additionally screen for:
• Monosomy X (Turner syndrome)
• Sex chromosome trisomies
• 22q11.2 deletion syndrome (optional)
• Trisomy 21 (Down syndrome)
• Trisomy 18 (Edwards syndrome)
• Trisomy 13 (Patau syndrome)
• Triploidy
• Monosomy X (Turner syndrome)
• Sex chromosome trisomies
• Microdeletions, including 22q11.2 deletion syndrome (optional)
• Gender (optional)
Singleton pregnancies:
What does Panorama screen for?
Panorama is the only NIPT that can tell the difference between the mother’s and the baby’s DNA, which results in:
• Fewer false positives and fewer false negatives
• The highest reported gender accuracy of any NIPT (gender reporting is optional)
• The ability to detect triploidy, a severe chromosomal abnormality that can result in serious pregnancy complications if unmonitored
• The ability to distinguish whether twins are identical or fraternal.
How is Panorama different?
NIPT:
• Screens for genetic abnormalities such as Down syndrome
• Can identify your baby’s gender (optional)
• Provides substantially fewer incorrect results than maternal serum screening or other prenatal blood tests
• Can be done as early as nine weeks into your pregnancy
• Poses no risk to your baby
The Panorama prenatal screen is a DNA screening test. Panorama provides you with information about the chance that your baby has certain genetic conditions.
Non-invasive prenatal testing (NIPT) uses a blood sample from the mother to analyze DNA from the placenta for certain chromosome conditions that could affect a baby’s health.
PANORAMA - NEXT GENERATION NIPT
POWERED BY NATERA
Discover more about your baby’s health
Our adress: 33 Frederick St N,
Dublin 1, Ireland
Appointments by phone: +353 86 411 0003
Appointments by email: feminamcltd@gmail.com
Copyright Femina MC 2023 All rights reserved.
Site design: